At the beginning of the next season, he joined English Premier League club Wigan Athletic, initially on a year long loan deal. He made his debut for Wigan on 19 August 2006, in a 2“1 loss to Newcastle United, and scored his first goal for them against Manchester City on 21 October 2006.The loan was extended into the following season, and on 18 January 2008 he transferred for an undisclosed fee, signing a three and a half year contract. In early June 2009, the Wigan chairman announced that he would not force Valencia to stay at the club.
On 30 June 2009, Valencia became Manchester United's first summer signing, having cut his holiday short to have a medical with the club. He has signed a four-year contract for an undisclosed fee, rumoured to be in the region of £16 million.